Hoffenheim vs Lyon: kick-off time, team news and prediction (Europa League)

Ligue 1 leaders Lyon, with six points from six in the Europa League, visit pointless Hoffenheim without Pavel Šulc and Lois Openda. Kick-off time, team news and our prediction.

By , Founder and publication director · · UEFA Europa League · 1 min read

La PreZero Arena de Sinsheim, où Hoffenheim reçoit l'Olympique Lyonnais
Photo : Photographs by Radosław Drożdżewski (User:Zwiadowca21) / Wikimedia Commons, CC BY-SA 4.0 · resized

Hoffenheim host Lyon at the PreZero Arena on Thursday 22 October 2026, kick-off 20:00 (Cameroon time), on matchday 3 of the Europa League. Match centre.

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  • 22:00 in Nairobi, Kampala, Dar es Salaam

Form

Lyon won 2-1 at Anderlecht and 3-2 against Crystal Palace last Thursday, then came from behind to beat Nice 2-1 on Sunday (Šulc, Tessmann) despite Keito Nakamura's red card. They top Ligue 1 on 14 points, on goal difference. Hoffenheim lost 2-0 at OFI and 3-2 to Beşiktaş, and have won three of nine games this season, the latest 2-1 at Mönchengladbach on Saturday (dpa).

Team news

  • Pavel Šulc did not travel with a knee problem; Paulo Fonseca named 18-year-old Rémi Himbert to start in his place.
  • Lois Openda, Nicolas Tagliafico and Mohamed Ouédraogo are injured. Nakamura is in the squad: his ban applies to Ligue 1 only.
  • Hoffenheim are without Nathan De Cat, Albian Hajdari and Patrick Wimmer, according to Sports Mole.

The table

Lyon are 8th on 6 points, the last direct qualifying spot for the last 16. Hoffenheim are 30th on 0.

Head to head

Three meetings, three draws: 3-3 and 2-2 in the 2018-19 Champions League, 2-2 in the Europa League in November 2024.

Our prediction

UEFA Europa League · Today 20:00 TSG Hoffenheim vs Lyon
TSG Hoffenheim21 % Draw18 % Lyon61 %
Over 2.5 goals 79 % Both teams score 73 %
Our pick : Lyon
Our model, a Poisson model based on recent goals scored and conceded, gives Hoffenheim 21%, the draw 18% and Lyon 61%. Most likely score according to our model: 1-2. It sees over 2.5 goals in 79% of cases and both teams scoring in 73%. It does not account for the absences of Šulc and Openda.

Also on Thursday: Sturm Graz vs Marseille preview.

A prediction is a probability, never a certainty. Betting is for people aged 21 and over.

Sources

FAQ

What time is Hoffenheim vs Lyon?

On Thursday 22 October 2026 at 20:00 (Cameroon time), at the PreZero Arena in Sinsheim.

What is the prediction for Hoffenheim vs Lyon?

Our model: Hoffenheim 21%, draw 18%, Lyon 61%. Most likely score: 1-2. Over 2.5 goals: 79%; both teams to score: 73%.

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